Assay Detail
Binding
CHEMBL675124
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Affinity constant of compound was evaluated in rat striatum tissue preparation.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.89 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.77 |
| CHEMBL8475 | — | — | 1 | 9.37 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.96 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 8.82 |
| CHEMBL8945 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8946 | ETICLOPRIDE | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL8475 | — | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL8809 | RACLOPRIDE | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL26 | SULPIRIDE | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL8945 | — | Kd | = | 31.1 | nM | 7.51 |