Assay Detail
Binding
CHEMBL675337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human Elastase
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Chymotrypsin-like elastase family member 1 (CHEMBL3000) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.67 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130253 | — | — | 1 | 9.24 |
| CHEMBL336171 | — | — | 1 | 9.00 |
| CHEMBL130271 | — | — | 1 | 7.85 |
| CHEMBL337396 | — | — | 1 | 7.36 |
| CHEMBL446422 | — | — | 1 | 6.80 |
| CHEMBL436383 | — | — | 1 | 6.70 |
| CHEMBL130128 | — | — | 2 | 6.60 |
| CHEMBL131188 | — | — | 1 | 6.52 |
| CHEMBL132768 | — | — | 1 | 6.18 |
| CHEMBL131780 | — | — | 1 | 6.07 |
| CHEMBL340062 | — | — | 1 | 5.37 |
| CHEMBL130718 | — | — | 2 | 4.39 |
| CHEMBL130006 | — | — | 1 | - |
| CHEMBL339870 | — | — | 1 | - |
| CHEMBL132171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130253 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL336171 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL130271 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL337396 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL446422 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL436383 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL130128 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL131188 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL132768 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL131780 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL340062 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL130128 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL130718 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL130006 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL339870 | — | Ki | = | 1000000.0 | nM | - |
| CHEMBL132171 | — | Ki | > | 1500000.0 | nM | - |
| CHEMBL130718 | — | Ki | > | 800000.0 | nM | - |