Assay Detail
Binding
CHEMBL675476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.65 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72657 | — | — | 1 | 7.06 |
| CHEMBL25554 | — | — | 1 | 6.91 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 6.53 |
| CHEMBL286565 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72657 | — | Ki | = | 86.48 | nM | 7.06 |
| CHEMBL25554 | — | Ki | = | 122.8 | nM | 6.91 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 294.9 | nM | 6.53 |
| CHEMBL286565 | — | Ki | = | 827.3 | nM | 6.08 |