Assay Detail
Binding
CHEMBL675480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand in rat striatum
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological activity of a macrocyclic benzamide
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.00 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164169 | — | — | 1 | 9.55 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 7.92 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.54 |
| CHEMBL301039 | — | — | 2 | - |
| CHEMBL164425 | — | — | 1 | - |
| CHEMBL28992 | — | — | 1 | - |
| CHEMBL116913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164169 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL325109 | CLEBOPRIDE | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL301039 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL164425 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL28992 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL116913 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL301039 | — | Ki | > | 1000.0 | nM | - |