Assay Detail
Binding
CHEMBL675482
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In vitro displacement of [3H]spiperone from Dopamine receptor D2 binding site in rat striatum.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.31 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58792 | FLUANISONE | 2.0 | 1 | 8.51 |
| CHEMBL105345 | — | — | 1 | 8.48 |
| CHEMBL105747 | — | — | 1 | 8.48 |
| CHEMBL104515 | ANISOPIROL | 2.0 | 1 | 8.47 |
| CHEMBL104805 | — | — | 1 | 8.39 |
| CHEMBL58377 | — | — | 1 | 8.30 |
| CHEMBL294633 | — | — | 1 | 8.28 |
| CHEMBL107141 | — | — | 1 | 8.19 |
| CHEMBL323982 | — | — | 1 | 8.00 |
| CHEMBL106854 | — | — | 1 | 7.89 |
| CHEMBL81728 | — | — | 1 | 7.85 |
| CHEMBL419910 | — | — | 1 | 7.77 |
| CHEMBL108229 | — | — | 1 | 7.64 |
| CHEMBL278799 | — | — | 1 | 7.19 |
| CHEMBL104204 | — | — | 1 | 7.14 |
| CHEMBL104578 | — | — | 1 | 7.04 |
| CHEMBL107903 | — | — | 1 | 6.89 |
| CHEMBL1742477 | FLESINOXAN | 2.0 | 1 | 6.85 |
| CHEMBL104593 | — | — | 1 | 6.64 |
| CHEMBL107336 | — | — | 1 | 6.60 |
| CHEMBL26447 | — | — | 1 | 6.24 |
| CHEMBL61032 | — | — | 1 | 6.11 |
| CHEMBL282614 | ELTOPRAZINE | 2.0 | 1 | 5.96 |
| CHEMBL104591 | — | — | 1 | 5.96 |
| CHEMBL9666 | — | — | 1 | 5.92 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 5.17 |
| CHEMBL106413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58792 | FLUANISONE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL105345 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL105747 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL104515 | ANISOPIROL | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL104805 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL58377 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL294633 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL107141 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL323982 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL106854 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL81728 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL419910 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL108229 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL278799 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL104204 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL104578 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL107903 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1742477 | FLESINOXAN | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL104593 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL107336 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL26447 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL61032 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL282614 | ELTOPRAZINE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL104591 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL9666 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL106413 | — | Ki | > | 10000.0 | nM | - |