Assay Detail
Binding
CHEMBL675484
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Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.76 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85689 | — | — | 1 | 6.47 |
| CHEMBL86325 | — | — | 1 | 6.41 |
| CHEMBL87734 | — | — | 1 | 6.23 |
| CHEMBL86669 | — | — | 1 | 6.20 |
| CHEMBL84983 | — | — | 1 | 6.17 |
| CHEMBL315750 | — | — | 1 | 6.14 |
| CHEMBL315005 | — | — | 1 | 6.12 |
| CHEMBL315468 | — | — | 1 | 6.11 |
| CHEMBL85409 | — | — | 1 | 6.11 |
| CHEMBL86931 | — | — | 1 | 6.09 |
| CHEMBL431220 | — | — | 1 | 6.08 |
| CHEMBL313304 | — | — | 1 | 5.98 |
| CHEMBL315849 | — | — | 1 | 5.97 |
| CHEMBL314459 | — | — | 1 | 5.95 |
| CHEMBL313530 | — | — | 1 | 5.89 |
| CHEMBL86576 | — | — | 1 | 5.89 |
| CHEMBL87910 | — | — | 1 | 5.83 |
| CHEMBL415080 | — | — | 1 | 5.68 |
| CHEMBL315516 | — | — | 1 | 5.61 |
| CHEMBL84557 | — | — | 1 | 5.58 |
| CHEMBL87172 | — | — | 1 | 5.58 |
| CHEMBL87897 | — | — | 1 | 5.57 |
| CHEMBL2115213 | — | — | 1 | 5.45 |
| CHEMBL83080 | — | — | 1 | 5.34 |
| CHEMBL87958 | — | — | 1 | 5.34 |
| CHEMBL420604 | — | — | 1 | 5.33 |
| CHEMBL420972 | — | — | 1 | 5.26 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 5.16 |
| CHEMBL82899 | — | — | 1 | 5.09 |
| CHEMBL420788 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85689 | — | Ki | = | 342.0 | nM | 6.47 |
| CHEMBL86325 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL87734 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL86669 | — | Ki | = | 636.0 | nM | 6.20 |
| CHEMBL84983 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL315750 | — | Ki | = | 724.0 | nM | 6.14 |
| CHEMBL315005 | — | Ki | = | 764.0 | nM | 6.12 |
| CHEMBL315468 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL85409 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL86931 | — | Ki | = | 807.0 | nM | 6.09 |
| CHEMBL431220 | — | Ki | = | 825.0 | nM | 6.08 |
| CHEMBL313304 | — | Ki | = | 1055.0 | nM | 5.98 |
| CHEMBL315849 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL314459 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL86576 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL313530 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL87910 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL415080 | — | Ki | = | 2090.0 | nM | 5.68 |
| CHEMBL315516 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL84557 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL87172 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL87897 | — | Ki | = | 2710.0 | nM | 5.57 |
| CHEMBL2115213 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL83080 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL87958 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL420604 | — | Ki | = | 4680.0 | nM | 5.33 |
| CHEMBL420972 | — | Ki | = | 5540.0 | nM | 5.26 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 6870.0 | nM | 5.16 |
| CHEMBL82899 | — | Ki | = | 8190.0 | nM | 5.09 |
| CHEMBL420788 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL85552 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL2114209 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL315535 | — | Ki | > | 10000.0 | nM | - |