Assay Detail
Binding
CHEMBL675636
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Inhibitory concentration of EGF dependent autophosphorylation of epidermal growth factor receptor kinase
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 4.91 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77030 | TYRPHOSTIN 47 | — | 1 | 6.07 |
| CHEMBL310798 | TYRPHOSTIN 25 | — | 1 | 6.00 |
| CHEMBL80155 | — | — | 1 | 5.66 |
| CHEMBL296407 | — | — | 1 | 5.46 |
| CHEMBL309598 | — | — | 1 | 5.35 |
| CHEMBL76905 | — | — | 1 | 5.00 |
| CHEMBL76904 | TYRPHOSTIN 23 | — | 1 | 4.96 |
| CHEMBL311119 | — | — | 1 | 4.70 |
| CHEMBL77085 | — | — | 1 | 4.62 |
| CHEMBL76642 | — | — | 1 | 4.62 |
| CHEMBL308134 | — | — | 1 | 4.31 |
| CHEMBL77298 | — | — | 1 | 4.30 |
| CHEMBL307179 | — | — | 1 | 4.26 |
| CHEMBL77869 | — | — | 1 | 4.17 |
| CHEMBL73820 | — | — | 1 | 4.16 |
| CHEMBL421877 | — | — | 1 | - |
| CHEMBL77524 | — | — | 1 | - |
| CHEMBL307250 | — | — | 1 | - |
| CHEMBL76983 | — | — | 1 | - |
| CHEMBL77436 | — | — | 1 | - |
| CHEMBL77724 | — | — | 1 | - |
| CHEMBL307248 | — | — | 1 | - |
| CHEMBL78005 | — | — | 1 | - |
| CHEMBL77778 | — | — | 1 | - |
| CHEMBL77595 | — | — | 1 | - |
| CHEMBL76979 | — | — | 1 | - |
| CHEMBL78150 | TYRPHOSTIN A9 | — | 1 | - |
| CHEMBL310400 | — | — | 1 | - |
| CHEMBL66879 | COUMARIC ACID | — | 1 | - |
| CHEMBL420385 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77030 | TYRPHOSTIN 47 | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL310798 | TYRPHOSTIN 25 | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL80155 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL296407 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL309598 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL76905 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL76904 | TYRPHOSTIN 23 | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL311119 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL77085 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL76642 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL308134 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL77298 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL307179 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL77869 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL73820 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL76557 | — | Ki | = | 360000.0 | nM | - |
| CHEMBL78174 | — | Ki | = | 143000.0 | nM | - |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | Ki | = | 308000.0 | nM | - |
| CHEMBL77387 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL78184 | — | Ki | = | 2500000.0 | nM | - |
| CHEMBL76985 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | Ki | = | 400000.0 | nM | - |
| CHEMBL77197 | — | Ki | = | 341000.0 | nM | - |
| CHEMBL305695 | — | Ki | = | 160000.0 | nM | - |
| CHEMBL77278 | — | Ki | = | 1350000.0 | nM | - |
| CHEMBL421877 | — | Ki | = | 300000.0 | nM | - |
| CHEMBL77524 | — | Ki | = | 2500000.0 | nM | - |
| CHEMBL307250 | — | Ki | = | 800000.0 | nM | - |
| CHEMBL76983 | — | Ki | > | 400000.0 | nM | - |
| CHEMBL77436 | — | Ki | = | 1400000.0 | nM | - |
| CHEMBL77724 | — | Ki | > | 400000.0 | nM | - |
| CHEMBL307248 | — | Ki | = | 240000.0 | nM | - |
| CHEMBL78005 | — | Ki | = | 117000.0 | nM | - |
| CHEMBL77778 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL77595 | — | Ki | > | 2500000.0 | nM | - |
| CHEMBL76979 | — | Ki | = | 700000.0 | nM | - |
| CHEMBL78150 | TYRPHOSTIN A9 | Ki | = | 155000.0 | nM | - |
| CHEMBL310400 | — | Ki | = | 123000.0 | nM | - |
| CHEMBL66879 | COUMARIC ACID | Ki | = | 1000000.0 | nM | - |
| CHEMBL420385 | — | Ki | > | 250000.0 | nM | - |