Assay Detail
Binding
CHEMBL675669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human Dopamine receptor D3 expressed in CHO cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.57 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34239 | — | — | 1 | 5.57 |
| CHEMBL38262 | — | — | 1 | 5.57 |
| CHEMBL37706 | — | — | 1 | - |
| CHEMBL37604 | — | — | 1 | - |
| CHEMBL37169 | — | — | 1 | - |
| CHEMBL35114 | — | — | 1 | - |
| CHEMBL267014 | L-745870 | — | 1 | - |
| CHEMBL38349 | — | — | 1 | - |
| CHEMBL35182 | — | — | 1 | - |
| CHEMBL37638 | — | — | 1 | - |
| CHEMBL36337 | — | — | 1 | - |
| CHEMBL287078 | — | — | 1 | - |
| CHEMBL290351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34239 | — | Ki | = | 2682.0 | nM | 5.57 |
| CHEMBL38262 | — | Ki | = | 2682.0 | nM | 5.57 |
| CHEMBL37706 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL37604 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL37169 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL35114 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL267014 | L-745870 | Ki | > | 3030.0 | nM | - |
| CHEMBL38349 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL35182 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL37638 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL36337 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL287078 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL290351 | — | Ki | > | 3000.0 | nM | - |