Assay Detail
Binding
CHEMBL675725
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Binding affinity which represents concentration giving half-maximal inhibition of [3H]spiperone (Dopamine receptor D2) binding to rat tissue homogenate
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.42 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120512 | — | — | 3 | 8.69 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.16 |
| CHEMBL333246 | — | — | 1 | 7.16 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.62 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120512 | — | Ki | = | 2.06 | nM | 8.69 |
| CHEMBL120512 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL120512 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL715 | OLANZAPINE | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL333246 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL26 | SULPIRIDE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL42 | CLOZAPINE | Ki | = | 250.0 | nM | 6.60 |