Assay Detail
Binding
CHEMBL675726
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Binding affinity against Dopamine receptor D2 in CHO-K1 cells using radioligand [3H]NPA binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.51 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108531 | — | — | 1 | 9.17 |
| CHEMBL109101 | — | — | 1 | 8.72 |
| CHEMBL110489 | — | — | 1 | 8.39 |
| CHEMBL108532 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108531 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL109101 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL110489 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL108532 | — | Ki | = | 18.0 | nM | 7.75 |