Assay Detail
Binding
CHEMBL675732
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Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.94 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274491 | — | — | 1 | 9.92 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 8.66 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.02 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 7.41 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 2 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274491 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL325109 | CLEBOPRIDE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 235.0 | nM | 6.63 |