Assay Detail
Binding
CHEMBL675742
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Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]IABN radioligand.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.45 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54866 | — | — | 1 | 10.30 |
| CHEMBL52588 | — | — | 1 | 9.70 |
| CHEMBL54667 | — | — | 1 | 8.74 |
| CHEMBL51959 | — | — | 1 | 8.26 |
| CHEMBL52298 | — | — | 1 | 8.24 |
| CHEMBL54865 | — | — | 1 | 8.23 |
| CHEMBL50465 | — | — | 1 | 8.01 |
| CHEMBL53102 | — | — | 1 | 7.94 |
| CHEMBL298759 | — | — | 1 | 7.93 |
| CHEMBL298875 | — | — | 1 | 7.92 |
| CHEMBL53778 | — | — | 1 | 7.72 |
| CHEMBL53320 | — | — | 1 | 7.72 |
| CHEMBL301929 | — | — | 1 | 7.64 |
| CHEMBL53078 | — | — | 1 | 7.64 |
| CHEMBL54662 | — | — | 1 | 7.58 |
| CHEMBL53038 | — | — | 1 | 7.24 |
| CHEMBL54571 | — | — | 1 | 7.23 |
| CHEMBL51754 | — | — | 1 | 7.21 |
| CHEMBL52300 | — | — | 1 | 7.20 |
| CHEMBL54026 | — | — | 1 | 7.13 |
| CHEMBL301302 | — | — | 1 | 7.12 |
| CHEMBL301732 | — | — | 1 | 7.10 |
| CHEMBL51856 | — | — | 1 | 7.03 |
| CHEMBL50352 | — | — | 1 | 7.02 |
| CHEMBL416846 | — | — | 1 | 6.88 |
| CHEMBL423122 | — | — | 1 | 6.82 |
| CHEMBL53650 | — | — | 1 | 6.82 |
| CHEMBL298864 | — | — | 1 | 6.82 |
| CHEMBL416481 | — | — | 1 | 6.80 |
| CHEMBL54092 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54866 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL52588 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL54667 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL51959 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL52298 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL54865 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL50465 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL53102 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL298759 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL298875 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL53778 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL53320 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL301929 | — | Ki | = | 22.9 | nM | 7.64 |
| CHEMBL53078 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL54662 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL53038 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL54571 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL51754 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL52300 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL54026 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL301302 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL301732 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL51856 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL50352 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL416846 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL53650 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL298864 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL423122 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL416481 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL54092 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL50517 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL54027 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL53218 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL52835 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL53401 | — | Ki | = | 771.0 | nM | 6.11 |