Assay Detail
Binding
CHEMBL675757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 0.1 nM of [125I]- (S)-N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide binding in striatal homogenates of rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-[125I]iodo- 2-methoxybenzamide hydrochloride, a new selective radioligand for dopamine D-2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.57 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.92 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.89 |
| CHEMBL49897 | IODOPRIDE | — | 1 | 8.82 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.48 |
| CHEMBL2115023 | — | — | 1 | 6.95 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.22 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL49897 | IODOPRIDE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL26 | SULPIRIDE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2115023 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL62 | SCH-23390 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL59 | DOPAMINE | IC50 | = | 1860.0 | nM | 5.73 |