Assay Detail
Binding
CHEMBL675759
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Inhibition of [3H]N-propylnorapomorphine binding to Dopamine receptor D2 of rat striatal membranes
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.90 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276500 | — | — | 2 | 6.74 |
| CHEMBL106257 | — | — | 1 | 6.59 |
| CHEMBL106028 | — | — | 1 | 6.39 |
| CHEMBL93428 | — | — | 1 | 6.22 |
| CHEMBL1203001 | — | — | 1 | 6.04 |
| CHEMBL1203007 | — | — | 1 | 5.40 |
| CHEMBL1203004 | — | — | 1 | 5.29 |
| CHEMBL1203003 | — | — | 1 | 5.27 |
| CHEMBL1202201 | — | — | 1 | 5.19 |
| CHEMBL1203002 | — | — | 1 | 5.00 |
| CHEMBL108682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276500 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL276500 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL106257 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL106028 | — | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL93428 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL1203001 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL1203007 | — | IC50 | = | 3985.0 | nM | 5.40 |
| CHEMBL1203004 | — | IC50 | = | 5132.0 | nM | 5.29 |
| CHEMBL1203003 | — | IC50 | = | 5328.0 | nM | 5.27 |
| CHEMBL1202201 | — | IC50 | = | 6396.0 | nM | 5.19 |
| CHEMBL1203002 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL108682 | — | IC50 | > | 1000.0 | nM | - |