Assay Detail
Binding
CHEMBL675800
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Binding towards Dopamine receptor D2 using [3H]spiperone from rat striatal membrane
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.51 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.70 |
| CHEMBL278751 | — | — | 1 | 7.16 |
| CHEMBL276500 | — | — | 2 | 7.00 |
| CHEMBL90359 | — | — | 1 | 6.39 |
| CHEMBL27441 | — | — | 1 | 6.28 |
| CHEMBL107492 | — | — | 2 | 5.94 |
| CHEMBL110821 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL278751 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL276500 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL90359 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL27441 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL276500 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL107492 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL110821 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL107492 | — | Ki | = | 12600.0 | nM | 4.90 |