Assay Detail
Binding
CHEMBL675803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenate
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.92 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 9.40 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.30 |
| CHEMBL2111781 | — | — | 1 | 8.68 |
| CHEMBL118889 | — | — | 1 | 8.51 |
| CHEMBL121274 | — | — | 1 | 8.44 |
| CHEMBL64875 | — | — | 1 | 8.44 |
| CHEMBL120512 | — | — | 1 | 8.42 |
| CHEMBL333955 | — | — | 1 | 8.40 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.32 |
| CHEMBL116542 | — | — | 1 | 8.30 |
| CHEMBL2111783 | — | — | 2 | 8.26 |
| CHEMBL119687 | — | — | 1 | 8.22 |
| CHEMBL333455 | — | — | 1 | 8.02 |
| CHEMBL2111782 | — | — | 2 | 7.72 |
| CHEMBL118919 | — | — | 1 | 7.66 |
| CHEMBL332600 | — | — | 1 | 7.62 |
| CHEMBL118092 | — | — | 1 | 7.52 |
| CHEMBL368324 | — | — | 1 | 7.30 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.16 |
| CHEMBL333246 | — | — | 1 | 7.10 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL64249 | CLOROTEPINE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2111781 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL118889 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL121274 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL64875 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL120512 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL333955 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL116542 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2111783 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL119687 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL333455 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL2111782 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL118919 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL332600 | — | Ki | = | 23.7 | nM | 7.62 |
| CHEMBL118092 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL368324 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL715 | OLANZAPINE | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL333246 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL2111783 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL42 | CLOZAPINE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2111782 | — | Ki | = | 601.0 | nM | 6.22 |