Assay Detail
Binding
CHEMBL675838
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In vitro inhibition of [3H]haloperidol (HPD) binding to dopamine (DA) receptor of rat striatal membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dopamine autoreceptor agonists as potential antipsychotics. 1. (Aminoalkoxy)anilines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.74 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44231 | — | — | 1 | 7.80 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.57 |
| CHEMBL43913 | — | — | 1 | 7.17 |
| CHEMBL44450 | — | — | 1 | 6.86 |
| CHEMBL43844 | — | — | 1 | 6.62 |
| CHEMBL42576 | — | — | 1 | 6.45 |
| CHEMBL42764 | — | — | 1 | 6.33 |
| CHEMBL7393 | — | — | 1 | 6.03 |
| CHEMBL44449 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44231 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL43913 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL44450 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL43844 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL42576 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL42764 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL7393 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL44449 | — | IC50 | = | 1571.0 | nM | 5.80 |