Assay Detail
Binding
CHEMBL675868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace [3H]spiroperidol from rat dopamine receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.67 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.70 |
| CHEMBL33022 | — | — | 1 | 8.30 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.85 |
| CHEMBL289889 | — | — | 1 | 7.80 |
| CHEMBL285682 | — | — | 1 | 7.80 |
| CHEMBL36177 | — | — | 1 | 7.75 |
| CHEMBL34250 | — | — | 1 | 7.70 |
| CHEMBL32914 | — | — | 1 | 7.64 |
| CHEMBL34245 | — | — | 1 | 7.50 |
| CHEMBL413743 | — | — | 1 | 7.47 |
| CHEMBL407641 | MEZILAMINE | 2.0 | 1 | 7.40 |
| CHEMBL417146 | — | — | 1 | 7.36 |
| CHEMBL35491 | — | — | 1 | 7.28 |
| CHEMBL35287 | — | — | 1 | 7.14 |
| CHEMBL34491 | — | — | 1 | 7.00 |
| CHEMBL34874 | — | — | 1 | 6.93 |
| CHEMBL35125 | — | — | 1 | 6.92 |
| CHEMBL417676 | — | — | 1 | 6.85 |
| CHEMBL288330 | — | — | 1 | 6.85 |
| CHEMBL285690 | — | — | 1 | 6.73 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.50 |
| CHEMBL418221 | — | — | 1 | 6.42 |
| CHEMBL32777 | — | — | 1 | 6.32 |
| CHEMBL35502 | — | — | 1 | 6.19 |
| CHEMBL286107 | — | — | 1 | 6.10 |
| CHEMBL284956 | — | — | 1 | 6.00 |
| CHEMBL32664 | — | — | 1 | 5.80 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 5.80 |
| CHEMBL34820 | — | — | 1 | 5.52 |
| CHEMBL34246 | IPROZILAMINE | 2.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL33022 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL289889 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL285682 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL36177 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL34250 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL32914 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL34245 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL413743 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL407641 | MEZILAMINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL417146 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL35491 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL35287 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL34491 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL34874 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL35125 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL417676 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL288330 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL285690 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL42 | CLOZAPINE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL418221 | — | Ki | = | 385.0 | nM | 6.42 |
| CHEMBL32777 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL35502 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL286107 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL284956 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL32664 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL26 | SULPIRIDE | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL34820 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL34246 | IPROZILAMINE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL287509 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL35759 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL32554 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL36410 | — | Ki | = | 40000.0 | nM | 4.40 |