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Assay Detail

CHEMBL675883

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]raclopride binding at Dopamine receptor D2 from rat striata.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.
Norman MH, Minick DJ, Rigdon GC.
J Med Chem (1996) 39 : 149 -157
PubMed 8568802 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.96 8.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL41309 1 8.12
CHEMBL38409 1 8.04
CHEMBL41536 1 7.68
CHEMBL288930 1 7.62
CHEMBL54 HALOPERIDOL 4.0 1 7.40
CHEMBL41626 1 7.37
CHEMBL43410 1 7.37
CHEMBL41636 1 7.36
CHEMBL291070 1 7.36
CHEMBL290937 1 7.31
CHEMBL43069 1 6.89
CHEMBL38747 1 6.77
CHEMBL288450 1 6.75
CHEMBL290953 1 6.66
CHEMBL36423 1 6.57
CHEMBL42 CLOZAPINE 4.0 1 6.54
CHEMBL39226 1 6.47
CHEMBL289275 1 6.16
CHEMBL441430 1 6.16
CHEMBL559330 1 5.96
CHEMBL43513 1 5.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL41309 IC50 = 7.6 nM 8.12
CHEMBL38409 IC50 = 9.2 nM 8.04
CHEMBL41536 IC50 = 21.0 nM 7.68
CHEMBL288930 IC50 = 24.0 nM 7.62
CHEMBL54 HALOPERIDOL IC50 = 40.0 nM 7.40
CHEMBL41626 IC50 = 43.0 nM 7.37
CHEMBL43410 IC50 = 43.0 nM 7.37
CHEMBL41636 IC50 = 44.0 nM 7.36
CHEMBL291070 IC50 = 44.0 nM 7.36
CHEMBL290937 IC50 = 49.0 nM 7.31
CHEMBL43069 IC50 = 130.0 nM 6.89
CHEMBL38747 IC50 = 170.0 nM 6.77
CHEMBL288450 IC50 = 180.0 nM 6.75
CHEMBL290953 IC50 = 220.0 nM 6.66
CHEMBL36423 IC50 = 270.0 nM 6.57
CHEMBL42 CLOZAPINE IC50 = 290.0 nM 6.54
CHEMBL39226 IC50 = 340.0 nM 6.47
CHEMBL289275 IC50 = 700.0 nM 6.16
CHEMBL441430 IC50 = 700.0 nM 6.16
CHEMBL559330 IC50 = 1100.0 nM 5.96
CHEMBL43513 IC50 = 2800.0 nM 5.55