Assay Detail
Binding
CHEMBL675884
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In vitro affinity for rat striatal Dopamine receptor D2 labeled with [3H]spiperone
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123338 | — | — | 1 | 8.70 |
| CHEMBL1204189 | TIOSPIRONE HYDROCHLORIDE | -1.0 | 1 | 8.10 |
| CHEMBL124291 | — | — | 1 | 8.00 |
| CHEMBL332147 | — | — | 1 | 7.64 |
| CHEMBL123653 | — | — | 1 | 7.60 |
| CHEMBL331227 | — | — | 1 | 7.52 |
| CHEMBL1203226 | — | — | 1 | 7.38 |
| CHEMBL1203225 | — | — | 1 | 7.31 |
| CHEMBL1203220 | — | — | 1 | 7.28 |
| CHEMBL1203224 | — | — | 1 | 7.26 |
| CHEMBL121774 | — | — | 1 | 7.23 |
| CHEMBL331221 | — | — | 1 | 7.19 |
| CHEMBL420164 | — | — | 1 | 7.16 |
| CHEMBL121065 | — | — | 1 | 7.11 |
| CHEMBL123133 | — | — | 1 | 6.84 |
| CHEMBL122100 | — | — | 1 | 6.84 |
| CHEMBL123121 | — | — | 1 | 6.69 |
| CHEMBL123048 | — | — | 1 | 6.63 |
| CHEMBL332241 | — | — | 1 | 6.62 |
| CHEMBL333257 | — | — | 1 | 6.44 |
| CHEMBL124119 | — | — | 1 | 6.36 |
| CHEMBL124047 | — | — | 1 | 6.06 |
| CHEMBL1204336 | — | — | 1 | - |
| CHEMBL123834 | — | — | 1 | - |
| CHEMBL1203222 | — | — | 1 | - |
| CHEMBL1203223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123338 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1204189 | TIOSPIRONE HYDROCHLORIDE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL124291 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL332147 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL123653 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL331227 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1203226 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1203225 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1203220 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1203224 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL121774 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL331221 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL420164 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL121065 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL123133 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL122100 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL123121 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL123048 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL332241 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL333257 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL124119 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL124047 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1204336 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL123834 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1203222 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1203223 | — | IC50 | > | 1000.0 | nM | - |