Assay Detail
Binding
CHEMBL675889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound required to inhibit the binding of radioligand [3H]spiperone to Dopamine receptor D2 in rat brain synaptic membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.16 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38969 | — | — | 1 | 7.75 |
| CHEMBL39016 | — | — | 1 | 7.37 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38969 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL39016 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | = | 444.0 | nM | 6.35 |