Assay Detail
Binding
CHEMBL675896
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Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]spiperone as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.70 |
| CHEMBL59103 | — | — | 1 | 7.02 |
| CHEMBL445102 | — | — | 1 | 7.00 |
| CHEMBL268799 | — | — | 1 | 6.82 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.70 |
| CHEMBL59324 | — | — | 1 | 6.55 |
| CHEMBL267014 | L-745870 | — | 1 | 5.64 |
| CHEMBL57478 | — | — | 1 | 5.17 |
| CHEMBL60518 | — | — | 1 | - |
| CHEMBL57535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL59103 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL445102 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL268799 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL42 | CLOZAPINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL59324 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL267014 | L-745870 | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL57478 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL60518 | — | Ki | > | 4500.0 | nM | - |
| CHEMBL57535 | — | Ki | > | 3700.0 | nM | - |