Assay Detail
Binding
CHEMBL675920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranes
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.45 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 7.80 |
| CHEMBL1237325 | — | — | 1 | 7.72 |
| CHEMBL1237323 | — | — | 1 | 7.60 |
| CHEMBL1237331 | — | — | 1 | 7.60 |
| CHEMBL1237320 | — | — | 1 | 7.54 |
| CHEMBL1237333 | — | — | 1 | 7.52 |
| CHEMBL70887 | — | — | 1 | 7.51 |
| CHEMBL1237324 | — | — | 1 | 7.46 |
| CHEMBL306960 | — | — | 1 | 7.42 |
| CHEMBL1237339 | — | — | 1 | 7.34 |
| CHEMBL1237338 | — | — | 1 | 7.34 |
| CHEMBL1237332 | — | — | 1 | 7.29 |
| CHEMBL1237330 | — | — | 1 | 7.22 |
| CHEMBL1237343 | — | — | 1 | 7.07 |
| CHEMBL307717 | — | — | 1 | 7.04 |
| CHEMBL431786 | — | — | 1 | 6.70 |
| CHEMBL1237327 | — | — | 1 | 6.58 |
| CHEMBL73461 | IRINDALONE | 2.0 | 2 | 6.40 |
| CHEMBL305905 | — | — | 1 | 6.39 |
| CHEMBL1237326 | — | — | 1 | 6.24 |
| CHEMBL308123 | — | — | 1 | 6.17 |
| CHEMBL1237341 | — | — | 1 | 6.10 |
| CHEMBL267795 | — | — | 1 | 6.03 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 5.75 |
| CHEMBL1237335 | — | — | 1 | 5.72 |
| CHEMBL76004 | — | — | 1 | 5.72 |
| CHEMBL1237337 | — | — | 1 | 5.40 |
| CHEMBL1237328 | — | — | 1 | 5.35 |
| CHEMBL1237336 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1237325 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1237331 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1237323 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1237320 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1237333 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL70887 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1237324 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL306960 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1237338 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1237339 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1237332 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1237330 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1237343 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL307717 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL431786 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1237327 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL73461 | IRINDALONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL305905 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1237326 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL308123 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1237341 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL267795 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL51 | KETANSERIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1237335 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL76004 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1237337 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1237328 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL73461 | IRINDALONE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL308076 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1237336 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2 | PRAZOSIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1237344 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL306939 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL312285 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL307465 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL74759 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL72644 | — | IC50 | > | 1000.0 | nM | - |