Assay Detail
Binding
CHEMBL675925
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Inhibitory activity against Dopamine receptor D2 in rat corpus striatum using [3H]Apomorphine as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Corpus striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.06 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.80 |
| CHEMBL78548 | — | — | 1 | 6.48 |
| CHEMBL311225 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL531 | PERGOLIDE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL78548 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL311225 | — | IC50 | = | 1233.0 | nM | 5.91 |