Assay Detail
Binding
CHEMBL676050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.49 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274491 | — | — | 1 | 9.31 |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | 7.77 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.50 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 6.77 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274491 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL325109 | CLEBOPRIDE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL267044 | LEVOSULPIRIDE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | = | 820.0 | nM | 6.09 |