Assay Detail
Binding
CHEMBL676053
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Inhibitory concentration against [3H]U-86170 binding to Dopamine receptor D2 expressed in CHO-K1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.31 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75207 | — | — | 1 | 6.31 |
| CHEMBL81623 | — | — | 1 | - |
| CHEMBL81665 | — | — | 1 | - |
| CHEMBL311378 | — | — | 1 | - |
| CHEMBL3706602 | — | — | 1 | - |
| CHEMBL310745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75207 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL81623 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL81665 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL311378 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3706602 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL310745 | — | IC50 | > | 1000.0 | nM | - |