Assay Detail
Binding
CHEMBL676060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]spiperone binding to Dopamine D2 receptor in rat striatum.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.36 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335545 | CI-1007 | — | 1 | 7.28 |
| CHEMBL118219 | — | — | 1 | 7.12 |
| CHEMBL119273 | — | — | 1 | 7.00 |
| CHEMBL117527 | — | — | 1 | 6.95 |
| CHEMBL2111778 | — | — | 1 | 6.95 |
| CHEMBL116205 | — | — | 1 | 6.85 |
| CHEMBL451189 | — | — | 1 | 6.77 |
| CHEMBL324085 | — | — | 1 | 6.48 |
| CHEMBL119191 | — | — | 1 | 6.45 |
| CHEMBL119339 | — | — | 1 | 6.38 |
| CHEMBL327070 | — | — | 1 | 6.37 |
| CHEMBL116261 | — | — | 1 | 6.20 |
| CHEMBL333053 | — | — | 1 | 6.00 |
| CHEMBL119575 | — | — | 1 | 5.59 |
| CHEMBL120197 | — | — | 1 | 5.41 |
| CHEMBL118721 | — | — | 1 | 5.33 |
| CHEMBL118461 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335545 | CI-1007 | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL118219 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL119273 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL117527 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL2111778 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL116205 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL451189 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL324085 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL119191 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL119339 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL327070 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL116261 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL333053 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL119575 | — | IC50 | = | 2554.0 | nM | 5.59 |
| CHEMBL120197 | — | IC50 | = | 3936.0 | nM | 5.41 |
| CHEMBL118721 | — | IC50 | = | 4634.0 | nM | 5.33 |
| CHEMBL118461 | — | IC50 | = | 9207.0 | nM | 5.04 |