Assay Detail
Binding
CHEMBL676061
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Tested for its affinity towards D2 receptor in rat striatal membrane
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.10 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219916 | DOMPERIDONE | 3.0 | 1 | 8.55 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 3 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219916 | DOMPERIDONE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 87.7 | nM | 7.06 |
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 1250.0 | nM | 5.90 |