Assay Detail
Binding
CHEMBL676108
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Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cardiac atrium |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Endothelin: a new challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.68 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437472 | ENDOTHELIN | 2.0 | 1 | 10.47 |
| CHEMBL4524099 | — | — | 1 | 10.06 |
| CHEMBL1790180 | ENDOTHELIN 3 | 0.5 | 1 | 8.80 |
| CHEMBL4524100 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437472 | ENDOTHELIN | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL4524099 | — | Ki | = | 0.087 | nM | 10.06 |
| CHEMBL1790180 | ENDOTHELIN 3 | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4524100 | — | Ki | = | 4200.0 | nM | 5.38 |