Assay Detail
Binding
CHEMBL676130
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat brain limbic tissue
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Limbic system |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.61 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202507 | — | — | 1 | 7.80 |
| CHEMBL1202512 | — | — | 1 | 7.28 |
| CHEMBL28406 | — | — | 1 | 7.19 |
| CHEMBL31319 | — | — | 1 | 7.13 |
| CHEMBL1202513 | — | — | 1 | 7.07 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.92 |
| CHEMBL1202494 | — | — | 1 | 6.85 |
| CHEMBL28352 | — | — | 1 | 6.61 |
| CHEMBL1204094 | — | — | 1 | 6.46 |
| CHEMBL412258 | — | — | 1 | 6.46 |
| CHEMBL28453 | — | — | 1 | 6.43 |
| CHEMBL284203 | — | — | 1 | 6.38 |
| CHEMBL1202504 | — | — | 1 | 6.31 |
| CHEMBL29155 | — | — | 1 | 6.16 |
| CHEMBL281215 | — | — | 1 | 6.01 |
| CHEMBL424409 | — | — | 1 | 5.72 |
| CHEMBL29218 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202507 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1202512 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL28406 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL31319 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL1202513 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL49 | BUSPIRONE | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL1202494 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL28352 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL1204094 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL412258 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL28453 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL284203 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL1202504 | — | Ki | = | 488.0 | nM | 6.31 |
| CHEMBL29155 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL281215 | — | Ki | = | 968.0 | nM | 6.01 |
| CHEMBL424409 | — | Ki | = | 1925.0 | nM | 5.72 |
| CHEMBL29218 | — | Ki | = | 2334.0 | nM | 5.63 |