Assay Detail
Binding
CHEMBL676133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]raclopride binding to rat striatal dopamine receptor D2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.75 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289330 | — | — | 1 | 10.74 |
| CHEMBL176458 | — | — | 1 | 10.62 |
| CHEMBL76402 | — | — | 1 | 10.19 |
| CHEMBL171921 | — | — | 1 | 9.82 |
| CHEMBL435670 | — | — | 1 | 9.72 |
| CHEMBL175082 | — | — | 1 | 9.37 |
| CHEMBL283099 | — | — | 1 | 9.26 |
| CHEMBL2096749 | — | — | 1 | 9.10 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289330 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL176458 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL76402 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL171921 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL435670 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL175082 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL283099 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL2096749 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 1.3 | nM | 8.89 |