Assay Detail
Binding
CHEMBL676134
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In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]spiperone radioligand in rat striatal membranes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.72 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61671 | — | — | 1 | 8.69 |
| CHEMBL435182 | — | — | 1 | 8.55 |
| CHEMBL60265 | — | — | 1 | 8.52 |
| CHEMBL292253 | — | — | 1 | 8.37 |
| CHEMBL305585 | — | — | 1 | 8.26 |
| CHEMBL303556 | — | — | 1 | 8.23 |
| CHEMBL62290 | — | — | 1 | 8.05 |
| CHEMBL59500 | — | — | 1 | 7.86 |
| CHEMBL64134 | — | — | 1 | 7.84 |
| CHEMBL59737 | — | — | 1 | 7.84 |
| CHEMBL304894 | — | — | 1 | 7.84 |
| CHEMBL294538 | — | — | 1 | 7.82 |
| CHEMBL64420 | — | — | 1 | 7.80 |
| CHEMBL300316 | — | — | 1 | 7.80 |
| CHEMBL60783 | — | — | 1 | 7.78 |
| CHEMBL294204 | — | — | 1 | 7.70 |
| CHEMBL59501 | — | — | 1 | 7.63 |
| CHEMBL60900 | — | — | 1 | 7.62 |
| CHEMBL60361 | — | — | 1 | 7.53 |
| CHEMBL60840 | — | — | 1 | 7.48 |
| CHEMBL64509 | — | — | 1 | 7.42 |
| CHEMBL64283 | — | — | 1 | 7.41 |
| CHEMBL61665 | — | — | 1 | 7.33 |
| CHEMBL64345 | — | — | 1 | 7.22 |
| CHEMBL64508 | — | — | 1 | 6.94 |
| CHEMBL64238 | — | — | 1 | 6.83 |
| CHEMBL302436 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61671 | — | Ki | = | 2.06 | nM | 8.69 |
| CHEMBL435182 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL60265 | — | Ki | = | 3.03 | nM | 8.52 |
| CHEMBL292253 | — | Ki | = | 4.27 | nM | 8.37 |
| CHEMBL305585 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL303556 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL62290 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL59500 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL64134 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL59737 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL304894 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL294538 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL64420 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL300316 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL60783 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL294204 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL59501 | — | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL60900 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL60361 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL60840 | — | Ki | = | 32.9 | nM | 7.48 |
| CHEMBL64509 | — | Ki | = | 38.4 | nM | 7.42 |
| CHEMBL64283 | — | Ki | = | 39.3 | nM | 7.41 |
| CHEMBL61665 | — | Ki | = | 46.7 | nM | 7.33 |
| CHEMBL64345 | — | Ki | = | 59.5 | nM | 7.22 |
| CHEMBL64508 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL64238 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL302436 | — | Ki | = | 916.0 | nM | 6.04 |