Assay Detail
Binding
CHEMBL676136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.17 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25213 | — | — | 1 | 9.59 |
| CHEMBL22682 | — | — | 1 | 9.31 |
| CHEMBL25215 | — | — | 1 | 9.24 |
| CHEMBL25663 | — | — | 1 | 8.76 |
| CHEMBL21475 | — | — | 1 | 8.75 |
| CHEMBL22802 | — | — | 1 | 8.75 |
| CHEMBL278806 | — | — | 1 | 8.45 |
| CHEMBL22328 | — | — | 1 | 7.67 |
| CHEMBL38288 | — | — | 1 | 6.75 |
| CHEMBL22778 | — | — | 2 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25213 | — | Ki | = | 0.259 | nM | 9.59 |
| CHEMBL22682 | — | Ki | = | 0.489 | nM | 9.31 |
| CHEMBL25215 | — | Ki | = | 0.581 | nM | 9.24 |
| CHEMBL25663 | — | Ki | = | 1.75 | nM | 8.76 |
| CHEMBL21475 | — | Ki | = | 1.79 | nM | 8.75 |
| CHEMBL22802 | — | Ki | = | 1.76 | nM | 8.75 |
| CHEMBL278806 | — | Ki | = | 3.53 | nM | 8.45 |
| CHEMBL22328 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL38288 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL22778 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL22778 | — | Ki | = | 614.0 | nM | 6.21 |