Assay Detail
Binding
CHEMBL676154
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Inhibition of Epidermal growth factor receptor tyrosine kinase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87084 | — | — | 1 | 5.30 |
| CHEMBL86664 | — | — | 1 | - |
| CHEMBL68423 | — | — | 1 | - |
| CHEMBL280069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87084 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL86664 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL68423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL280069 | — | IC50 | > | 10000.0 | nM | - |