Assay Detail
Binding
CHEMBL676709
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Tested for binding affinity towards rat striatal D2 receptor using [3H]spiperone as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.92 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.73 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.76 |
| CHEMBL335545 | CI-1007 | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL53 | APOMORPHINE | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL335545 | CI-1007 | Ki | = | 53.0 | nM | 7.28 |