Assay Detail
Functional
CHEMBL677174
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Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GLC4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and cytotoxicity of novel lignans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.49 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 6.92 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.82 |
| CHEMBL292945 | — | — | 1 | 6.60 |
| CHEMBL67077 | — | — | 1 | 5.70 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 5.55 |
| CHEMBL28941 | — | — | 1 | 5.51 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.40 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.34 |
| CHEMBL302952 | — | — | 1 | 5.14 |
| CHEMBL302662 | — | — | 1 | 4.48 |
| CHEMBL503644 | — | — | 1 | 4.24 |
| CHEMBL304828 | — | — | 1 | 4.12 |
| CHEMBL63962 | — | — | 1 | - |
| CHEMBL406473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL61 | PODOFILOX | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL292945 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL67077 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL28941 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL302952 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL302662 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL503644 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL304828 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL63962 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL406473 | — | IC50 | > | 100000.0 | nM | - |