Assay Detail
Functional
CHEMBL677175
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Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GLC4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and cytotoxicity of novel lignans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.54 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 8.10 |
| CHEMBL28941 | — | — | 1 | 7.52 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.22 |
| CHEMBL292945 | — | — | 1 | 7.22 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 6.32 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.09 |
| CHEMBL67077 | — | — | 1 | 6.08 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.96 |
| CHEMBL302952 | — | — | 1 | 5.77 |
| CHEMBL63962 | — | — | 1 | 5.19 |
| CHEMBL304828 | — | — | 1 | 5.06 |
| CHEMBL503644 | — | — | 1 | 5.00 |
| CHEMBL302662 | — | — | 1 | 5.00 |
| CHEMBL406473 | — | — | 1 | 5.00 |
| CHEMBL66550 | — | — | 1 | 4.54 |
| CHEMBL67524 | — | — | 1 | 4.46 |
| CHEMBL307347 | — | — | 1 | 4.44 |
| CHEMBL406265 | — | — | 1 | 4.40 |
| CHEMBL302109 | — | — | 1 | 4.36 |
| CHEMBL303690 | — | — | 1 | 4.32 |
| CHEMBL67625 | — | — | 1 | 4.27 |
| CHEMBL307350 | — | — | 1 | - |
| CHEMBL302717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL28941 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL61 | PODOFILOX | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL292945 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL67077 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL302952 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL63962 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL304828 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL503644 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL302662 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL406473 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL66550 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL67524 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL307347 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL406265 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL302109 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL303690 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL67625 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL307350 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL302717 | — | IC50 | > | 100000.0 | nM | - |