Assay Detail
Functional
CHEMBL677177
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Inhibitory activity against GLIOMA#112 cell line
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GLIOMA#112 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.33 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285863 | Tetrameric orthoplatinated p-isopropylbenzaldehyde thiosemicarbazone | — | 1 | 4.57 |
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | — | 2 | 4.46 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.21 |
| CHEMBL242106 | — | — | 1 | 4.12 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285863 | Tetrameric orthoplatinated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL242106 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 120000.0 | nM | - |