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Compound Detail

CHEMBL242106

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CC(C)c1ccc(/C=N/NC(N)=S)cc1

Basic Information

ChEMBL ID CHEMBL242106
Phase Preclinical
Structure Type MOL
InChI Key GCIARVDJUYGSFQ-NTUHNPAUSA-N
9
Targets
11
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

221.3
MW (Da)
1.98
ALogP
2
HBA
2
HBD
50.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H15N3S
MW 221.33
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -1.78

Activity Summary

IC50 11 meas. best 6.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.46 6.46 350.0 1
Tyrosinase
CHEMBL3318
IC50 5.55 5.55 2830.0 1
Jurkat
CHEMBL397
IC50 5.05 5.05 9000.0 1
Trypanosoma cruzi
CHEMBL368
IC50 4.7 4.7 19800.0 1
PAM
CHEMBL614229
IC50 4.19 4.125 65000.0 2
GLIOMA#112
CHEMBL614158
IC50 4.12 4.12 75000.0 1
HeLa
CHEMBL399
IC50 4.11 4.11 78000.0 1
GLIOMA#108
CHEMBL614504
IC50 4.01 4.01 98000.0 1
NIH3T3
CHEMBL614822
IC50 4.01 4.01 97000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine