Assay Detail
Functional
CHEMBL764606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against PAM cell line
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | PAM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.56 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | — | 2 | 5.10 |
| CHEMBL285863 | Tetrameric orthoplatinated p-isopropylbenzaldehyde thiosemicarbazone | — | 1 | 4.52 |
| CHEMBL242106 | — | — | 1 | 4.06 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL285863 | Tetrameric orthoplatinated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL242106 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 180000.0 | nM | - |
| CHEMBL11359 | CISPLATIN | IC50 | = | 164000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 150000.0 | nM | - |
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 150000.0 | nM | - |