Assay Detail
Functional
CHEMBL694205
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Inhibitory activity against HeLa cell line
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.74 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | — | 2 | 5.40 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.16 |
| CHEMBL285863 | Tetrameric orthoplatinated p-isopropylbenzaldehyde thiosemicarbazone | — | 1 | 4.70 |
| CHEMBL242106 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL285863 | Tetrameric orthoplatinated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL287290 | Tetrameric orthopalladated p-isopropylbenzaldehyde thiosemicarbazone | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL242106 | — | IC50 | = | 78000.0 | nM | 4.11 |