Assay Detail
Binding
CHEMBL677211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [gamma-32P]-ATP from Epidermal growth factor receptor in A431 cell-free extracts
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of 5-[(2,5-dihydroxybenzyl)amino]salicylic acid analogs as inhibitors of EGF receptor-associated protein tyrosine kinase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.10 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122397 | — | — | 1 | 6.05 |
| CHEMBL319620 | LAVENDUSTIN C | — | 1 | 5.40 |
| CHEMBL123045 | — | — | 1 | 5.27 |
| CHEMBL122260 | — | — | 1 | 5.01 |
| CHEMBL122785 | — | — | 1 | 4.99 |
| CHEMBL122721 | — | — | 1 | 4.57 |
| CHEMBL123046 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122397 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL319620 | LAVENDUSTIN C | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL123045 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL122260 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL122785 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL122721 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL123046 | — | IC50 | = | 41900.0 | nM | 4.38 |