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Assay Detail

CHEMBL677263

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Binding
Binding activity to ET-B receptor on bovine cerebellum membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Cerebellum
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Expert

Target

Endothelin receptor type B (CHEMBL4401)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor
Suzawa T, Shibata K, Tanaka T, Matsuda Y, Yamasaki M
Bioorg Med Chem Lett (1997) 7 : 1715 -1720
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.85 9.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL263855 1 9.62
CHEMBL414047 1 8.60
CHEMBL408437 1 8.42
CHEMBL384792 1 8.00
CHEMBL437472 ENDOTHELIN 2.0 1 6.00
CHEMBL407188 1 6.00
CHEMBL414168 1 5.52
CHEMBL436894 1 5.52
CHEMBL437610 1 5.52
CHEMBL429908 1 5.30
CHEMBL414740 1 -
CHEMBL416287 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL263855 IC50 = 0.24 nM 9.62
CHEMBL414047 IC50 = 2.5 nM 8.60
CHEMBL408437 IC50 = 3.8 nM 8.42
CHEMBL384792 IC50 = 10.0 nM 8.00
CHEMBL437472 ENDOTHELIN IC50 = 1000.0 nM 6.00
CHEMBL407188 IC50 = 1000.0 nM 6.00
CHEMBL414168 IC50 = 3000.0 nM 5.52
CHEMBL436894 IC50 = 3000.0 nM 5.52
CHEMBL437610 IC50 = 3000.0 nM 5.52
CHEMBL429908 IC50 = 5000.0 nM 5.30
CHEMBL414740 IC50 > 5000.0 nM -
CHEMBL416287 IC50 > 1000.0 nM -