Assay Detail
Functional
CHEMBL677537
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Inhibition of BALB/MK mouse epidermal keratinocyte proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.82 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7939 | CGP-53353 | — | 1 | 5.07 |
| CHEMBL7914 | — | — | 1 | 5.03 |
| CHEMBL8095 | — | — | 1 | 4.94 |
| CHEMBL7352 | — | — | 1 | 4.73 |
| CHEMBL8036 | — | — | 1 | 4.69 |
| CHEMBL7775 | — | — | 1 | 4.46 |
| CHEMBL8000 | — | — | 1 | - |
| CHEMBL7929 | — | — | 1 | - |
| CHEMBL268441 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7939 | CGP-53353 | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL7914 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL8095 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL7352 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL8036 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL7775 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL8000 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL7929 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL268441 | — | IC50 | > | 50000.0 | nM | - |