Compound Detail
CHEMBL7939
CGP-53353 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL7939 |
| Name | CGP-53353 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RONQPWQYDRPRGG-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
365.3
MW (Da)
4.34
ALogP
4
HBA
3
HBD
70.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.16 | 5.91 | 700.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.07 | 5.07 | 8500.0 | 1 |
| Protein kinase C (PKC) CHEMBL2093867 | IC50 | 4.5 | 4.5 | 32000.0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
| Platelet-derived growth factor receptor CHEMBL2096980 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 700.0 | nM | 6.16 | Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD) | 8151612 |
| Epidermal growth factor receptor | IC50 | = | 2200.0 | nM | 5.66 | Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cells | 8151612 |
| Unchecked | IC50 | = | 8500.0 | nM | 5.07 | Inhibition of BALB/MK mouse epidermal keratinocyte proliferation | 8151612 |
| Protein kinase C (PKC) | IC50 | = | 32000.0 | nM | 4.5 | Inhibitory activity was determined against protein kinase C (PKC) from porcine b... | 8151612 |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 50000.0 | nM | 4.3 | Inhibitory activity against c-src tyrosine kinase | 8151612 |
| Platelet-derived growth factor receptor | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 ce... | 8151612 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23398362 | 10.1042/bj20121418 | Insulin receptor | 4 |
| 23398362 | 10.1042/bj20121418 | Insulin-like growth factor 1 receptor | 4 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase mTOR | 4 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase HCK | 4 |
| 23398362 | 10.1042/bj20121418 | Protein kinase C beta type | 4 |
| 23398362 | 10.1042/bj20121418 | Cyclin-dependent kinase 5/CDK5 activator 1 | 4 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase Lck | 4 |
| 23398362 | 10.1042/bj20121418 | cGMP-dependent protein kinase 1 | 4 |
| 23398362 | 10.1042/bj20121418 | SRSF protein kinase 3 | 2 |
| 23398362 | 10.1042/bj20121418 | Fibroblast growth factor receptor 4 | 2 |
| 23398362 | 10.1042/bj20121418 | Fibroblast growth factor receptor 3 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 23398362 | 10.1042/bj20121418 | Cyclin-dependent kinase 2/cyclin A | 2 |
| 23398362 | 10.1042/bj20121418 | Aurora kinase A | 2 |
| 23398362 | 10.1042/bj20121418 | Tyrosine-protein kinase ABL2 | 2 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase Nek7 | 2 |
| 23398362 | 10.1042/bj20121418 | Serine/threonine-protein kinase MARK1 | 2 |
| 23398362 | 10.1042/bj20121418 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | 2 |
| 23398362 | 10.1042/bj20121418 | Dual specificity mitogen-activated protein kinase kinase 1 | 2 |
| 23398362 | 10.1042/bj20121418 | Mitogen-activated protein kinase 10 | 2 |
Data from ChEMBL 36 via Core Engine