Assay Detail
Functional
CHEMBL615685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BALB/c3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2096980) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.46 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7775 | — | — | 1 | 4.92 |
| CHEMBL7939 | CGP-53353 | — | 1 | 4.00 |
| CHEMBL8000 | — | — | 1 | - |
| CHEMBL7352 | — | — | 1 | - |
| CHEMBL7914 | — | — | 1 | - |
| CHEMBL7929 | — | — | 1 | - |
| CHEMBL8095 | — | — | 1 | - |
| CHEMBL268441 | — | — | 1 | - |
| CHEMBL8036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7775 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL7939 | CGP-53353 | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL8000 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7352 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7914 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8095 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268441 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8036 | — | IC50 | > | 100000.0 | nM | - |