Assay Detail
Binding
CHEMBL821534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against c-src tyrosine kinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.88 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7775 | — | — | 1 | 6.00 |
| CHEMBL267019 | — | — | 1 | 5.10 |
| CHEMBL268868 | DAPH | — | 1 | 4.80 |
| CHEMBL7939 | CGP-53353 | — | 1 | 4.30 |
| CHEMBL8095 | — | — | 1 | 4.19 |
| CHEMBL266969 | — | — | 1 | - |
| CHEMBL267941 | — | — | 1 | - |
| CHEMBL7914 | — | — | 1 | - |
| CHEMBL266255 | — | — | 1 | - |
| CHEMBL8223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7775 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267019 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL268868 | DAPH | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL7939 | CGP-53353 | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL8095 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL266969 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL267941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7914 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL266255 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL8223 | — | IC50 | > | 100000.0 | nM | - |