Compound Detail
CHEMBL8223
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Basic Information
| ChEMBL ID | CHEMBL8223 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZIUKVZLABPRJTA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
471.6
MW (Da)
5.75
ALogP
6
HBA
3
HBD
76.7
PSA (Ų)
0.33
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 50000.0 | nM | 4.3 | Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD) | 8151612 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8151612 | 10.1021/jm00033a019 | Epidermal growth factor receptor | 1 |
| 8151612 | 10.1021/jm00033a019 | Tyrosine-protein kinase ABL | 1 |
| 8151612 | 10.1021/jm00033a019 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 8151612 | 10.1021/jm00033a019 | Protein kinase C (PKC) | 1 |
| 8151612 | 10.1021/jm00033a019 | cAMP-dependent protein kinase alpha-catalytic subunit | 1 |
Data from ChEMBL 36 via Core Engine