Assay Detail
Binding
CHEMBL679549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.62 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268868 | DAPH | — | 1 | 6.52 |
| CHEMBL7939 | CGP-53353 | — | 1 | 6.16 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.00 |
| CHEMBL8095 | — | — | 1 | 5.70 |
| CHEMBL267019 | — | — | 1 | 5.60 |
| CHEMBL7914 | — | — | 1 | 5.60 |
| CHEMBL7775 | — | — | 1 | 5.06 |
| CHEMBL8223 | — | — | 1 | 4.30 |
| CHEMBL8000 | — | — | 1 | - |
| CHEMBL8091 | — | — | 1 | - |
| CHEMBL8271 | — | — | 1 | - |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | - |
| CHEMBL266487 | RO-316233 | — | 1 | - |
| CHEMBL267941 | — | — | 1 | - |
| CHEMBL7352 | — | — | 1 | - |
| CHEMBL8222 | — | — | 1 | - |
| CHEMBL7929 | — | — | 1 | - |
| CHEMBL267869 | — | — | 1 | - |
| CHEMBL266255 | — | — | 1 | - |
| CHEMBL8163 | — | — | 1 | - |
| CHEMBL268441 | — | — | 1 | - |
| CHEMBL266969 | — | — | 1 | - |
| CHEMBL8036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268868 | DAPH | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL7939 | CGP-53353 | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL44 | GENISTEIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL8095 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL267019 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL7914 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL7775 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL8223 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL8000 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8091 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | > | 100000.0 | nM | - |
| CHEMBL266487 | RO-316233 | IC50 | > | 50000.0 | nM | - |
| CHEMBL267941 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL7352 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL8222 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL7929 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL267869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL266255 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8163 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL268441 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL266969 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL8036 | — | IC50 | > | 50000.0 | nM | - |