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Assay Detail

CHEMBL677662

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration to show 50% of activity was measured on Epstein Barr virus(EBV) cell culture
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human gammaherpesvirus 4
Confidence 1 — Organism
Curated By Expert

Target

Human gammaherpesvirus 4 (CHEMBL613124)
Type ORGANISM
Organism Human gammaherpesvirus 4

Publication

Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
Choi Y, Li L, Grill S, Gullen E, Lee CS, Gumina G, Tsujii E, Cheng YC, Chu CK.
J Med Chem (2000) 43 : 2538 -2546
PubMed 10891113 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 5.88 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85809 1 7.48
CHEMBL87698 1 6.72
CHEMBL81962 1 6.31
CHEMBL314382 1 6.23
CHEMBL86202 1 5.41
CHEMBL184 ACYCLOVIR 4.0 1 4.71
CHEMBL2092771 2 4.33
CHEMBL31634 BRIVUDINE 2.0 2 -
CHEMBL312839 1 -
CHEMBL85923 1 -
CHEMBL87439 1 -
CHEMBL83129 1 -
CHEMBL441063 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85809 EC50 = 33.0 nM 7.48
CHEMBL87698 EC50 = 190.0 nM 6.72
CHEMBL81962 EC50 = 490.0 nM 6.31
CHEMBL314382 EC50 = 590.0 nM 6.23
CHEMBL86202 EC50 = 3910.0 nM 5.41
CHEMBL184 ACYCLOVIR EC50 = 19700.0 nM 4.71
CHEMBL2092771 EC50 = 47000.0 nM 4.33
CHEMBL2092771 EC50 > 50000.0 nM -
CHEMBL31634 BRIVUDINE EC50 > 50000.0 nM -
CHEMBL312839 EC50 > 50000.0 nM -
CHEMBL85923 EC50 > 50000.0 nM -
CHEMBL87439 EC50 > 50000.0 nM -
CHEMBL83129 EC50 > 50000.0 nM -
CHEMBL31634 BRIVUDINE EC50 > 50000.0 nM -
CHEMBL441063 EC50 > 50000.0 nM -